Yan Weng Selected Research

Fatty Liver

1/2022	Effect of a Ketohexokinase Inhibitor (PF-06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug.
11/2020	Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
9/2005	Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.

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Yan Weng Research Topics

Disease

8	Body Weight (Weight, Body) 11/2023 - 01/2005
7	Type 2 Diabetes Mellitus (MODY) 02/2024 - 04/2014
6	Inflammation (Inflammations) 02/2019 - 01/2012
5	Insulin Resistance 02/2024 - 01/2017
5	Neoplasms (Cancer) 11/2023 - 08/2007
5	Reperfusion Injury 07/2022 - 01/2013
5	Infarction (Infarctions) 02/2019 - 11/2013
4	Obesity 07/2022 - 03/2016
4	Hyperglycemia 01/2017 - 08/2006
3	Ischemic Stroke 12/2023 - 02/2019
3	Brain Ischemia (Cerebral Ischemia) 07/2022 - 01/2014
3	Fatty Liver 01/2022 - 09/2005
3	Wounds and Injuries (Trauma) 01/2021 - 12/2015
3	Chronic Renal Insufficiency 01/2020 - 01/2015
3	Diabetic Cardiomyopathies 01/2017 - 01/2015
2	Spondylosis 10/2023 - 06/2013
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 02/2023 - 06/2022
2	Fibrosis (Cirrhosis) 01/2023 - 08/2015
2	Developmental Dysplasia of the Hip 11/2022 - 05/2022
2	Non-alcoholic Fatty Liver Disease 07/2022 - 11/2020
2	Alcoholic Fatty Liver 07/2022 - 01/2021
2	Stroke (Strokes) 01/2022 - 01/2016
2	Metabolic Diseases (Metabolic Disease) 01/2021 - 01/2018
2	Weight Loss (Weight Reduction) 12/2017 - 03/2014
2	Ischemia 01/2017 - 01/2014
2	Diabetes Mellitus 04/2015 - 03/2014
2	Myocardial Ischemia (Ischemic Heart Diseases) 11/2013 - 01/2013
2	Lipidoses 09/2005 - 01/2005
1	Cachexia 11/2023
1	Injection Site Reaction 11/2023
1	Anorexia 11/2023
1	Rheumatoid Arthritis 10/2023
1	Traumatic Intracranial Hemorrhage 04/2023
1	Hematoma 04/2023
1	Adrenocortical Carcinoma 01/2023
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 07/2022
1	Polyps 06/2022
1	Hip Dislocation 05/2022
1	Alzheimer Disease (Alzheimer's Disease) 02/2022
1	Cerebral Palsy (Spastic Diplegia) 01/2022
1	Spasm (Spasms) 01/2022
1	Hypertriglyceridemia 01/2021
1	Hyperinsulinism (Hyperinsulinemia) 01/2021
1	Hyperlipidemias (Hyperlipidemia) 01/2021
1	Postherpetic Neuralgia 07/2020
1	Kidney Diseases (Kidney Disease) 01/2020

Drug/Important Bio-Agent (IBA)

5	EnzymesIBA 07/2022 - 11/2013
5	AntioxidantsIBA 01/2021 - 01/2014
5	LipidsIBA 01/2021 - 03/2016
4	FructoseIBA 07/2022 - 01/2017
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2015
4	Streptozocin (Streptozotocin)FDA Link 01/2021 - 08/2006
4	CytokinesIBA 02/2019 - 11/2013
4	PF-05231023IBA 01/2018 - 01/2015
3	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 04/2014
3	Blood Glucose (Blood Sugar)IBA 01/2020 - 01/2008
3	chikusetsu saponin IVaIBA 01/2020 - 12/2015
3	fibroblast growth factor 21IBA 01/2018 - 03/2016
3	AdiponectinIBA 12/2017 - 01/2016
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 01/2015
2	ketohexokinaseIBA 07/2022 - 01/2022
2	Neuroprotective AgentsIBA 07/2022 - 02/2019
2	Peroxidase (Myeloperoxidase)IBA 07/2018 - 11/2013
2	hsian-tsaoIBA 06/2008 - 01/2008
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 08/2007 - 09/2005
2	CholesterolIBA 09/2005 - 01/2005
1	Phosphotransferases (Kinase)IBA 02/2024
1	Glutamine (L-Glutamine)FDA Link 02/2024
1	acteosideIBA 12/2023
1	HMGB1 Protein (HMG1)IBA 12/2023
1	Monoclonal AntibodiesIBA 11/2023
1	Growth Differentiation Factor 15IBA 11/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2023
1	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 01/2023
1	Etoposide (VP 16)FDA LinkGeneric 01/2023
1	Mitotane (Lysodren)FDA Link 01/2023
1	Carboplatin (JM8)FDA LinkGeneric 01/2023
1	sintilimabIBA 01/2023
1	Protein Kinase C-epsilonIBA 07/2022
1	Heme Oxygenase-1IBA 07/2022
1	boswellic acidIBA 07/2022
1	Oxygen (Dioxygen)IBA 07/2022
1	SodiumIBA 02/2022
1	Peptides (Polypeptides)IBA 01/2022
1	AnionsIBA 01/2022
1	PalmitatesIBA 01/2021
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	Fibrinogen (Factor I)FDA Link 12/2019

Therapy/Procedure

6	Therapeutics 11/2023 - 01/2013
4	Cardiopulmonary Resuscitation (CPR) 07/2010 - 01/2005
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/2015 - 06/2013
2	Hip Replacement Arthroplasty (Total Hip Replacement) 11/2022 - 05/2022
1	Airway Management 10/2023
1	Drug Therapy (Chemotherapy) 07/2023
1	Neurosurgical Procedures 04/2023
1	Surgical Instruments (Clip) 02/2023
1	Endoscopes 06/2022
1	Osteotomy 05/2022
1	Psychology Biofeedback (Biofeedback) 01/2022
1	Extracorporeal Shockwave Therapy 07/2020